Basic and applied immunology in cestode infections: from Hymenolepis to Taenia and Echinococcus

被引:23
作者
Ito, A
机构
关键词
Echinococcus; Taenia; Hymenolepis; immunobiology; immunodiagnosis;
D O I
10.1016/S0020-7519(97)00118-5
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
In larval cestode infections, it is well established that the intermediate mammalian host infected with egg-derived metacestodes in the tissue becomes completely immune to reinfection with eggs, whereas autoinfection has been conceived to occur in Hymenolepis nana/mouse (and human) and Taenia solium/human systems when these hosts are initially infected with metacestode-derived adult tapeworms in the lumen. In this review paper, the first topic is immunobiology of H. nana/mouse system on the reinfection immunity in order to get critical information as to how the initially ingested parasite (eggs or metacestodes) can develop into adult worms and how autoinfection does or does not occur in immunocompetent mice, since H. nana can complete its whole Life cycle in the mouse intestinal tissue and lumen, When mice are infected with eggs (= oncospheres) of H. nana, they become immune to challenge infections with eggs within a few days (early response) and with cysticercoids within two weeks (late response), The initially established adult worms are expelled later (worm expulsion response), When mice are infected with cysticercoids, either derived from beetles or mice, they become immune to challenge infection with cysticercoids but not with eggs. Therefore, autoinfection occurs in the intestinal tissue for the establishment of cysticercoids in the tissue but never occurs in the intestinal lumen for the establishment of adult worms in immunocompetent mice. The second topic is vaccination trial against challenge infection with eggs of Asian Taenia in pigs. Pigs vaccinated with frozen oncospheres of Asian Taenia from Taiwan or Korea or T. saginata showed very strong resistance, whereas pigs vaccinated with those of T. solium showed partial resistance only. It is suggested that Asian Taenia is much closer to T. saginata than T. solium from the immunobiological viewpoint, The third topic is immunodiagnosis of echinococcosis and cysticercosis. Immunoblot analysis has revealed that Em18 (18 kDa component of crude antigens of Echinococcus multilocularis protoscolex) and glycoproteins of T. solium cysticerci are highly specific or unique to alveolar echinococcosis and cysticercosis, respectively. The fourth topic is discussion on miscellaneous prospects including laboratory animal models for echinococcosis and cysticercosis. (C) 1997 Australian Society for Parasitology. Published by Elsevier Science Ltd.
引用
收藏
页码:1203 / 1211
页数:9
相关论文
共 74 条
[1]   IMMUNODIAGNOSIS OF TAENIASIS BY COPROANTIGEN DETECTION [J].
ALLAN, JC ;
AVILA, G ;
NOVAL, JG ;
FLISSER, A ;
CRAIG, PS .
PARASITOLOGY, 1990, 101 :473-477
[2]   DIPSTICK DOT ELISA FOR THE DETECTION OF TAENIA COPROANTIGENS IN HUMANS [J].
ALLAN, JC ;
MENCOS, F ;
GARCIANOVAL, J ;
SARTI, E ;
FLISSER, A ;
WANG, Y ;
LIU, D ;
CRAIG, PS .
PARASITOLOGY, 1993, 107 :79-85
[3]   COPROANTIGEN DETECTION FOR IMMUNODIAGNOSIS OF ECHINOCOCCOSIS AND TAENIASIS IN DOGS AND HUMANS [J].
ALLAN, JC ;
CRAIG, PS ;
NOVAL, JG ;
MENCOS, F ;
LIU, D ;
WANG, Y ;
WEN, H ;
ZHOU, P ;
STRINGER, R ;
ROGAN, M ;
ZEYHLE, E .
PARASITOLOGY, 1992, 104 :347-355
[4]   HYMENOLEPIS-NANA - ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AND DELAYED-TYPE HYPERSENSITIVITY RESPONSE WITH MESENTERIC LYMPH-NODE CELLS IN MICE [J].
ASANO, K ;
MURAMATSU, K ;
OKAMOTO, K .
EXPERIMENTAL PARASITOLOGY, 1991, 72 (01) :24-32
[5]   HYMENOLEPIS-NANA - PASSIVE TRANSFER OF MOUSE IMMUNITY BY T-CELL SUBSET OF PHENOTYPE LYT-1 [J].
ASANO, K ;
SHINODA, M ;
NAKAMURA, F ;
OKAMOTO, K .
EXPERIMENTAL PARASITOLOGY, 1986, 61 (03) :373-378
[6]  
BEFUS AD, 1975, PARASITOLOGY, V61, P61
[7]   MOLECULAR VARIATION IN ECHINOCOCCUS [J].
BOWLES, J ;
MCMANUS, DP .
ACTA TROPICA, 1993, 53 (3-4) :291-305
[8]  
CHO S-Y, 1988, Korean Journal of Parasitology, V26, P87, DOI 10.3347/kjp.1988.26.2.87
[9]  
Colli C, 1975, Rev Inst Med Trop Sao Paulo, V17, P59
[10]   LOCATION OF TAENIA-PISIFORMIS, TAENIA-OVIS AND TAENIA-HYDATIGENA IN GUT OF DOG AND ITS EFFECT ON NET ENVIRONMENTAL CONTAMINATION WITH OVA [J].
COMAN, BJ ;
RICKARD, MD .
ZEITSCHRIFT FUR PARASITENKUNDE-PARASITOLOGY RESEARCH, 1975, 47 (04) :237-248