Deep brain stimulation surgery for Parkinson's disease: mechanisms and consequences

被引：50
作者：
Lozano, AM
Mahant, N
机构：
[1] Toronto Western Hosp, Res Inst, Dept Surg, Div Neurosurg, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada
来源：
PARKINSONISM & RELATED DISORDERS | 2004年 / 10卷
关键词：
Parkinson's disease; deep brain stimulation; subthalamic nucleus; globus pallidus; stereotactic neurosurgery;
D O I：
10.1016/j.parkreldis.2003.12.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Despite the introduction of new medications, motor fluctuations and dyskinesias disable a significant proportion of Parkinson's disease patients. This has lead to renewed interest in stereotactic neurosurgery. A skilled team is needed to ensure that patient assessment and selection, operative technique, intraoperative monitoring, and post-operative management are optimised. High frequency stimulation has similar effects to ablative surgery, and is generally preferred. The clinical effects and possible mechanisms of action of deep brain stimulation of the subthalamic nucleus and globus pallidus are reviewed. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：S49 / S57
页数：9
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