The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer's Disease: A Systematic Review

被引：110

作者：

Chang, Ya-Ting ^{[1
,2
]}

Chang, Wen-Neng ^{[1
]}

Tsai, Nai-Wen ^{[1
]}

Huang, Chih-Cheng ^{[1
]}

Kung, Chia-Te ^{[3
]}

Su, Yu-Jih ^{[2
,4
]}

Lin, Wei-Che ^{[5
]}

Cheng, Ben-Chung ^{[2
,4
]}

Su, Chih-Min ^{[2
,4
]}

Chiang, Yi-Fang ^{[1
]}

Lu, Cheng-Hsien ^{[1
,2
,3
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol,Kaohsiung Med Ctr, Kaohsiung 833, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan

[3] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Emergency Med,Kaohsiung Med Ctr, Kaohsiung 833, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Med,Kaohsiung Med Ctr, Kaohsiung 833, Taiwan

[5] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Radiol,Kaohsiung Med Ctr, Kaohsiung 833, Taiwan

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

MILD COGNITIVE IMPAIRMENT; AMYOTROPHIC-LATERAL-SCLEROSIS; CEREBROSPINAL-FLUID LEVELS; PLASMA-PROTEIN OXIDATION; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; VASCULAR DEMENTIA; VITAMIN-E; PROTEOMIC IDENTIFICATION; LIPOPROTEIN OXIDATION;

D O I：

10.1155/2014/182303

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

引用

页数：14

共 77 条

[1] Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment [J].