Asymmetric Reductive Amination by Combined Bronsted Acid and Transition-Metal Catalysis

被引：49

作者：

Klussmann, Martin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 39期

关键词：

amination; asymmetric catalysis; hydrogenation; organocatalysis; transition metals; TRANSFER HYDROGENATION; IMINES;

D O I：

10.1002/anie.200903765

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The best of both worlds: A combination of organocatalysis and transition-metal catalysis serve in the highly stereoselective and atom-economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chiral counteranion, while a chiral iridium complex catalyzes the reduction with elemental hydrogen. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：7124 / 7125

页数：2

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