Nano-immunotherapeutic strategies for targeted RNA delivery: Emphasizing the role of monocyte/macrophages as nanovehicles to treat glioblastoma multiforme

被引:5
作者
Manicum, Amanda-Lee Ezra [1 ]
Sargazi, Saman [2 ]
Razzaq, Sobia [3 ]
Kumar, Govindarajan Venkat [4 ]
Rahdar, Abbas [5 ]
Er, Simge [6 ]
Ul Ain, Qurrat [7 ]
Bilal, Muhammad [8 ]
Aboudzadeh, M. Ali [9 ]
机构
[1] Tshwane Univ Technol, Dept Chem, Fac Sci, Arcadia Campus, ZA-0001 Pretoria, South Africa
[2] Zahedan Univ Med Sci, Cellular & Mol Res Ctr, Res Inst Cellular & Mol Sci Infect Dis, Zahedan 9816743463, Iran
[3] Quaid I Azam Univ Islamabad, Dept Pharm, Islamabad 45320, Pakistan
[4] VSB Engn Coll, Dept Biotechnol, Karur 639111, Tamil Nadu, India
[5] Univ Zabol, Dept Phys, POB 98613-35856, Zabol, Iran
[6] Ege Univ, Biochem Dept, Fac Sci, TR-35100 Izmir, Turkey
[7] Bandung Inst Technol, Sch Pharm, Dept Pharmacol & Clin Pharm, Bandung 40132, Indonesia
[8] Huaiyin Inst Technol, Sch Life Sci & Food Engn, Huaian 223003, Peoples R China
[9] Univ Pau & Pays Adour, Inst Sci Analyt & Phys Chim Environm & Mat, UMR5254, IPREM,CNRS,E2S UPPA, F-64000 Pau, France
关键词
Glioblastoma multiforme; Immunotherapy; Nanotechnology; Targeted therapy; TUMOR-ASSOCIATED MACROPHAGES; SOLID LIPID NANOPARTICLES; IRON-OXIDE NANOPARTICLES; MESSENGER-RNA; DRUG-DELIVERY; IN-VIVO; SIRNA DELIVERY; CIRCULATING MONOCYTES; M(6)A MODIFICATION; MEDIATED DELIVERY;
D O I
10.1016/j.jddst.2022.103288
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Glioblastoma multiforme (GBM) is considered the most aggressive and heterogeneous type of brain malignancy. The substantial invasion of the central nervous system parenchyma is a typical hallmark of all grades of glioma. To improve tumor localization and prevent unanticipated toxicity, anti-tumor drug delivery mechanisms must be upgraded in parallel with pharmacotherapeutics. Monocytes can easily pass the blood-brain barrier, and thus, drugs with difficulty entering the brain can be loaded into monocytes, resulting in the treatment of brain cancers. RNA as a natural and biocompatible polymer has many advantages for biomedical applications, and RNA-based therapies can provide regulated biological functions by highly selective and controlling means. In this context, macrophages are excellent carriers for distributing RNA-based treatments. However, developing an efficient macrophage-targeted RNA delivery has remained challenging. Several approaches have been introduced in the last decade to efficiently deliver RNA-based therapy via macrophages to treat GBM and inflammatory conditions. This review summarizes the most suitable nano-carrier systems to deliver RNA into immunocytes; also, different methods of synthesizing RNA-loaded nanoparticles and their application, with an emphasis on targeting GBM, are discussed. Furthermore, it focuses specifically on the stability of such nanoformulations and the effect of targeting moieties and adjuvants in determining the worth of the aroused immune response. Finally, the critical aspects of delivering RNA-lipid hybrid nanoparticles (LNPs) via oral, systemic, and local routes are highlighted. We hope that these findings will pave the way for more effective treatment of solid tumors, such as GBM, in the future.
引用
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页数:23
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