Exhaled breath condensate biomarkers in critically ill, mechanically ventilated patients

被引：8

作者：

Davis, Michael D. ^{[1
]}

Winters, Brett R. ^{[2
]}

Madden, Michael C. ^{[3
]}

Pleil, Joachim D. ^{[4
]}

Sessler, Curtis N. ^{[5
]}

Wallace, M. Ariel Geer ^{[6
]}

Ward-Caviness, Cavin K. ^{[3
]}

Montpetit, Alison J. ^{[7
]}

机构：

[1] Indiana Univ, Riley Hosp Children, Wells Ctr Pediat Res Pulmonol Allergy & Sleep Med, 1044 W Walnut St R4-472, Indianapolis, IN 46202 USA

[2] GSI Environm Inc, Oakland, CA USA

[3] US EPA, Publ Hlth & Integrated Toxicol Div, Ctr Publ Hlth & Environm Assessment, Res Triangle Pk, NC 27711 USA

[4] Univ N Carolina, Gillings Sch Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA

[5] Virginia Commonwealth Univ, Dept Internal Med, Sch Med, Div Pulm Dis & Crit Care Med, Richmond, VA USA

[6] US EPA, Air Methods & Characterizat Div, Ctr Environm Measurement & Modeling, Res Triangle Pk, NC 27711 USA

[7] Patient Care Serv VCU Hlth Syst, Nursing Res & Innovat, Richmond, VA USA

来源：

JOURNAL OF BREATH RESEARCH | 2021年 / 15卷 / 01期

关键词：

exhaled breath condensate; cytokines; VAP; biomarkers; EBC; LUNG-FUNCTION; PNEUMONIA; DIAGNOSIS; EPIDEMIOLOGY; CYTOKINES; MORTALITY; OUTCOMES; SEPSIS; BLOOD; PH;

D O I：

10.1088/1752-7163/abc235

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pneumonia is a significant risk for critically ill, mechanically ventilated (CIMV) patients. Diagnosis of pneumonia generally requires a combination of clinician-guided diagnoses and clinical scoring systems. Exhaled breath condensate (EBC) can be safely collected non-invasively from CIMV patients. Hundreds of biomarkers in EBC are associated with acute disease states, including pneumonia. We evaluated cytokines in EBC from CIMV patients and hypothesized that these biomarkers would correlate with disease severity in pneumonia, sepsis, and death. EBC IL-2 levels were associated with chest radiograph severity scores (odds ratio = 1.68; 95% confidence interval = 1.09-2.60; P = 0.02). EBC TNF-alpha levels were also associated with pneumonia (odds ratio = 3.20; 95% confidence interval = 1.19-8.65; P = 0.02). The techniques and results from this study may be useful for all mechanically ventilated patients.

引用

页数：9

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