Peptides as a therapeutic strategy against Klebsiela pneumoniae

被引：28

作者：

de Souza, Camila Maurmann ^{[1
]}

da Silva, Allan Pires ^{[1
,2
]}

Oliveira Junior, Nelson Gomes ^{[1
]}

Martinez, Osmel Fleitas ^{[1
,2
]}

Franco, Octavio Luiz ^{[1
,2
]}

机构：

[1] Univ Catolica Brasilia, Ctr Anal Prote & Bioquim, Programa Posgrad Ciencias Genom & Biotecnol, BR-70790160 Brasilia, DF, Brazil

[2] Univ Catolica Dom Bosco, S Inova Biotech, Programa Posgrad Biotecnol, BR-79117900 Campo Grande, MS, Brazil

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2022年 / 43卷 / 04期

关键词：

ANTIMICROBIAL PEPTIDE; MULTIDRUG-RESISTANT; ANTIBACTERIAL ACTIVITY; COLISTIN-RESISTANT; DRUG-RESISTANT;

D O I：

10.1016/j.tips.2021.12.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increasing levels of resistance to conventional antibiotics have led to a search for new therapeutic options against bacterial infections. Klebsiella pneumoniae is considered a world health problem due to high levels of mortality associated with resistance to multiple antibiotics. Antimicrobial peptides (AMPs) have showed activity against this bacterium, which makes them a promising alternative in tackling resistance. In this article, we carried out an overview of the recent development of AMPs against K. pneumoniae using different designs and acting by different mechanisms, such as a recently proposed one against capsulated strains. Moreover, we outline AMPs' therapeutic potential when tested in combination with conventional antibiotics and against biofilms. Furthermore, challenges and perspectives for applying AMPs in clinical practice are discussed here.

引用

页码：335 / 348

页数：14

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