Precision Redox: The Key for Antioxidant Pharmacology

被引：70

作者：

Meng, Jiao ^{[1
]}

Lv, Zhenyu ^{[1
,2
]}

Zhang, Yingmin ^{[1
,2
]}

Wang, Yuanyuan ^{[1
,2
]}

Qiao, Xinhua ^{[1
]}

Sun, Chuanxin ^{[1
]}

Chen, Yuzhe ^{[1
,2
]}

Guo, Miaomiao ^{[1
,2
]}

Han, Wensheng ^{[1
,2
]}

Ye, Aojun ^{[1
,2
]}

Xie, Ting ^{[1
]}

Chu, Boyu ^{[1
,2
]}

Shi, Chang ^{[1
,2
]}

Yang, Shangpo ^{[1
]}

Chen, Chang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2021年 / 34卷 / 14期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

precision redox; antioxidants; redox status (state); ROS; RNS; oxidative; nitrosative stress; pharmacology; NITRIC-OXIDE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; S-NITROSATION; VITAMIN-C; ENDOPLASMIC-RETICULUM; REDUCTIVE STRESS; NUCLEAR EXPORT; BETA-CAROTENE; BREAST-CANCER;

D O I：

10.1089/ars.2020.8212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significance: The redox balance of cells provides a stable microenvironment for biological macromolecules to perform their physiological functions. As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based therapeutic strategies have not yet shown satisfactory results. To find the key reason is of great significance. Recent Advances: We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the "5R" principle of precision redox in antioxidant pharmacology: "Right species, Right place, Right time, Right level, and Right target." Critical Issues: Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population. Future Directions: Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the "5R" principle rather than continuing to apply global nonspecific antioxidant treatments.

引用

页码：1069 / 1082

页数：14

共 116 条

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