Glioblastoma in multiple sclerosis: a case report

被引:11
|
作者
Frisullo, Giovanni [1 ]
Patanella, Agata Katia [1 ,2 ]
Nociti, Viviana [1 ,2 ]
Cianfoni, Alessandro [3 ]
Iorio, Raffaele [1 ]
Bianco, Assunta [1 ]
Marti, Alessandro [1 ]
Tonali, Pietro Attilio [1 ,2 ]
Batocchi, Anna Paola [1 ]
机构
[1] Catholic Univ, Inst Neurol, Dept Neurosci, I-00168 Rome, Italy
[2] Fdn Don C Gnocchi, Rome, Italy
[3] Med Univ S Carolina, Dept Radiol, Neuroradiol Sect, Charleston, SC 29425 USA
关键词
Glioblastoma multiforme; Multiple sclerosis; Transcription factors; Differential diagnosis; MONONUCLEAR-CELLS; T-BET; EXPRESSION; OLIGODENDROGLIOMA; CONCURRENCE; GLIOMA; PSTAT1;
D O I
10.1007/s11060-009-9804-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.
引用
收藏
页码:141 / 144
页数:4
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