Glioblastoma in multiple sclerosis: a case report

被引：11

作者：

Frisullo, Giovanni ^{[1
]}

Patanella, Agata Katia ^{[1
,2
]}

Nociti, Viviana ^{[1
,2
]}

Cianfoni, Alessandro ^{[3
]}

Iorio, Raffaele ^{[1
]}

Bianco, Assunta ^{[1
]}

Marti, Alessandro ^{[1
]}

Tonali, Pietro Attilio ^{[1
,2
]}

Batocchi, Anna Paola ^{[1
]}

机构：

[1] Catholic Univ, Inst Neurol, Dept Neurosci, I-00168 Rome, Italy

[2] Fdn Don C Gnocchi, Rome, Italy

[3] Med Univ S Carolina, Dept Radiol, Neuroradiol Sect, Charleston, SC 29425 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2009年 / 94卷 / 01期

关键词：

Glioblastoma multiforme; Multiple sclerosis; Transcription factors; Differential diagnosis; MONONUCLEAR-CELLS; T-BET; EXPRESSION; OLIGODENDROGLIOMA; CONCURRENCE; GLIOMA; PSTAT1;

D O I：

10.1007/s11060-009-9804-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.

引用

页码：141 / 144

页数：4

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