Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis

被引：28

作者：

Strieter, RM

Keane, MP

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Div Pulm & Crit Care Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 02期

关键词：

D O I：

10.1172/JCI200422398

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3-expressing cells, specifically pulmonary NK cells, is necessary to produce IFN-gamma. This is critical in the polarization of the immune response to injury toward a favorable Th1 response and resolution. In contrast, a Th2 response is associated with progressive fibrosis (see the related article beginning on page 291).

引用

页码：165 / 168

页数：4

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