Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers

被引：63

作者：

Kaldor, SW

Fritz, JE

Tang, J

McKinney, ER

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00560-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solution phase parallel synthesis of equimolar mixtures of ureas was accomplished using a solid-supported ''covalent scavenger'' (aminomethylpolystyrene) to remove isocyanate impurities. Screening of these purified mixtures for antirhinoviral activity in a whole cell assay and subsequent deconvolution of hit mixtures afforded novel antirhinoviral agents with low cytotoxicities. Copyright (C) 1996 Elsevier Science Ltd

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页码：3041 / 3044

页数：4

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