Protein Electrochemistry: Application in Medicine. A Review

被引：53

作者：

Suprun, Elena V. ^{[1
]}

Shumyantseva, Victoria V. ^{[1
]}

Archakov, Alexander I. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Biomed Chem, Moscow 119121, Russia

来源：

ELECTROCHIMICA ACTA | 2014年 / 140卷

关键词：

Protein; Amino acid; Direct electrochemistry; Bioelectrocatalysis; Liquid-liquid interface; ACUTE MYOCARDIAL-INFARCTION; AMYLOID-BETA AGGREGATION; BORON-DOPED DIAMOND; MULTIWALLED CARBON NANOTUBES; SCREEN-PRINTED ELECTRODES; TYROSINE KINASE-ACTIVITY; HUMAN BLOOD-PLASMA; AMINO-ACIDS; CYTOCHROME-C; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.electacta.2014.03.089

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

This mini-review outlines the current state of knowledge in field of protein electrochemistry and its application in medicine. Protein electrochemistry is considered according to (i) its intrinsic redox activity as generated by prosthetic groups and/or amino acid residues as well as (ii) charge transfer or adsorption at interfaces between two immiscible electrolyte solutions (liquid-liquid interfaces). Despite protein electrochemistry already has experimental and theoretical basis, its potential applications in medicine where proteins serve as the most valuable biomarkers is not yet attended. Mediator-free and label-free protein detection, analysis of its denaturation and aggregation, measurement and regulation of enzyme activity, a search for new substrates and inhibitors-i.e. the major problems of protein research are treated in this mini-review from the electrochemical viewpoint. Significance of protein electrochemistry for clinical, pharmacological and scientific medicine is discussed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：72 / 82

页数：11

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