Liver cell-targeted delivery of therapeutic molecules

被引：52

作者：

Kang, Jeong-Hun ^{[1
]}

Toita, Riki ^{[2
]}

Murata, Masaharu ^{[3
,4
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr Res Inst, Div Biopharmaceut & Pharmacokinet, Dept Biomed Engn, Suita, Osaka 5658565, Japan

[2] Kyushu Univ, Fac Dent Sci, Dept Biomat, Fukuoka 812, Japan

[3] Kyushu Univ, Dept Adv Med Initiat, Fac Med Sci, Fukuoka 812, Japan

[4] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka 812, Japan

来源：

CRITICAL REVIEWS IN BIOTECHNOLOGY | 2016年 / 36卷 / 01期

关键词：

Drug delivery; endocytosis; gene delivery; hepetocyte; nanoparticle; polymer; viral vector; SINUSOIDAL ENDOTHELIAL-CELLS; HEPATIC STELLATE CELLS; LOW-DENSITY-LIPOPROTEIN; RECEPTOR-MEDIATED ENDOCYTOSIS; HYDRODYNAMIC GENE DELIVERY; BOVINE SERUM-ALBUMIN; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; MANNOSE-TERMINATED GLYCOPROTEINS; C VIRUS-REPLICATION; G IMMUNE-COMPLEXES;

D O I：

10.3109/07388551.2014.930017

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The liver is the largest internal organ in mammals and is involved in metabolism, detoxification, synthesis of proteins and lipids, secretion of cytokines and growth factors and immune/inflammatory responses. Hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic veno-occlusive disease, and liver fibrosis and cirrhosis are the most common liver diseases. Safe and efficient delivery of therapeutic molecules (drugs, genes or proteins) into the liver is very important to increase the clinical efficacy of these molecules and to reduce their side effects in other organs. Several liver cell-targeted delivery systems have been developed and tested in vivo or ex vivo/in vitro. In this review, we discuss the literature concerning liver cell-targeted delivery systems, with a particular emphasis on the results of in vivo studies.

引用

页码：132 / 143

页数：12