Structure-based design of Mcl-1 inhibitors: Interdiction at a protein-protein interface

被引：0
|
作者：
Brown, Sean [1 ]
机构：
[1] Amgen Inc, S San Fran, CA USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 252卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
202
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Interdiction at a protein-protein interface: Structure-based design and optimization of spirocyclic Mcl-1 inhibitors
    Li, Kexue
    Brown, Sean
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [2] Interdiction at a protein-protein interface: Structure-based design of the Mcl-1 inhibitor AMG 176
    Brown, Sean
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [3] Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology
    Li, Kexue
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 32
  • [4] Breaking the rules to interdiction at a protein-protein interface: Structure-based design of the Mcl-1 inhibitor AMG 176
    Brown, Sean
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [5] Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1
    Hargreaves, David
    Carbajo, Rodrigo J.
    Bodnarchuk, Michael S.
    Embrey, Kevin
    Rawlins, Philip B.
    Packer, Martin
    Degorce, Sebastien L.
    Hird, Alexander W.
    Johannes, Jeffrey W.
    Chiarparin, Elisabetta
    Schade, Markus
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (21)
  • [6] Structure-based design of functionalized salicylates as potent Mcl-1 inhibitors
    Chen, Lijia
    Chauhan, Jay
    Yap, Jeremy
    Wilder, Paul
    Fletcher, Steven
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [7] Structure-based design and development of pyrazolopyridine-based inhibitors of Mcl-1
    Abulwerdi, Fardokht A.
    Mady, Ahmed S. A.
    Perdih, Andrej
    Stuckey, Jeanne A.
    Showalter, Hollis D.
    Nikolovska-Coleska, Zaneta
    CANCER RESEARCH, 2014, 74 (19)
  • [8] The discovery of Mcl-1 inhibitors using fragment-based methods and structure-based design
    Fesik, Stephen W.
    CANCER RESEARCH, 2016, 76
  • [9] Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes
    Pelay-Gimeno, Marta
    Glas, Adrian
    Koch, Oliver
    Grossmann, Tom N.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (31) : 8896 - 8927
  • [10] Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors
    Zhu, Junjie
    Wang, Ziqian
    Guo, Zongwei
    Zhang, Xiaodong
    Song, Ting
    Guo, Yafei
    Ji, Tong
    Zhang, Zhichao
    ARCHIV DER PHARMAZIE, 2020, 353 (05)
12345