Y Chromosome as a Tool for DNA Identification and Determination of Ethnoterritorial Origin

被引:4
作者
Kharkov, V. N. [1 ]
Zarubin, A. A. [1 ]
Vagaitseva, K. V. [1 ]
Radzhabov, M. O. [2 ,3 ]
Novikova, L. M. [1 ]
Valikhova, L. V. [1 ]
Khitrinskaya, I. Y. [1 ]
Stepanov, V. A. [1 ]
机构
[1] Russian Acad Sci, Res Inst Med Genet, Tomsk Natl Res Med Ctr, Tomsk 634050, Russia
[2] Dagestan State Med Univ, Dept Personalized Med, Res Inst Ecol Med, Makhachkala 367000, Russia
[3] Russian Acad Sci, Dagestan Fed Res Ctr, Phys Inst, Makhachkala 367015, Russia
基金
俄罗斯基础研究基金会;
关键词
Y chromosome; DNA identification; genetic diversity; runs of homozygosity; human populations; SINGLE NUCLEOTIDE POLYMORPHISMS; SNPS; PANEL; GENETICS; UTILITY; ASSAY; STRS; LOCI;
D O I
10.1134/S1022795420090112
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Genetic diversity of a large number of populations is analyzed using various Y-chromosome markers. Genotyping of a wide range of novel highly informative SNP and YSTR markers shows that most of the Y-chromosome haplogroups can be divided not only into ethnically specific lineages but also into narrower sublineages and clusters of haplotypes. A significant extent of population and interethnic genetic differentiation is revealed. Most ethnic gene pools are characterized by the predominance or even complete dominance of specific SNPs across all major haplogroups, that is highly promising for the application in ethnic identification of biological samples of males.
引用
收藏
页码:1109 / 1117
页数:9
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