Full-field optical coherence microscopy with optimized ultrahigh spatial resolution

被引：26
作者：
Federici, Antoine [1 ]
Dubois, Arnaud [1 ]
机构：
[1] Univ Paris 11, Lab Charles Fabry, CNRS UMR 8501, Inst Opt,Grad Sch, F-91127 Palaiseau, France
来源：
OPTICS LETTERS | 2015年 / 40卷 / 22期
关键词：
HUMAN SKIN; TOMOGRAPHY;
D O I：
10.1364/OL.40.005347
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Full-field optical coherence microscopy (FF-OCM) with isotropic spatial resolution of 0.5 mu m (in water), at 700 nm center wavelength, is reported. A theoretical study of the FF-OCM axial response is carried out for maximizing the axial resolution of the system, considering the effect of optical dispersion. The lateral resolution is optimized by using water-immersion microscope objectives with a numerical aperture of 1.2. This ultrahigh-resolution FF-OCM system is applied to animal and human skin tissue imaging, revealing ultra-fine in-depth structures at the sub-cellular level. (C) 2015 Optical Society of America
引用
收藏
页码：5347 / 5350
页数：4
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