Prenatal screening and diagnosis of aneuploidy in multiple pregnancies

被引：6

作者：

Gagnon, Alain ^{[1
]}

Audibert, Francois ^{[2
]}

机构：

[1] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[2] Univ Montreal, Montreal, PQ, Canada

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2014年 / 28卷 / 02期

关键词：

prenatal screening; Down syndrome; aneuploidy; multiple pregnancies; amniocentesis; chorionic villus sampling; NUCHAL TRANSLUCENCY MEASUREMENT; TWIN PREGNANCIES; GENETIC AMNIOCENTESIS; DOWN-SYNDROME; 2ND-TRIMESTER AMNIOCENTESIS; ALPHA-FETOPROTEIN; METHYLENE-BLUE; TRISOMY-21; 1ST-TRIMESTER; RISK;

D O I：

10.1016/j.bpobgyn.2013.12.010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Prenatal screening for aneuploidy has changed significantly over the last 30 years, from being age-based to maternal serum and ultrasound based techniques. Multiple pregnancies present particular challenges with regards to screening as serum-based screening techniques are influenced by all feti while ultrasound-based techniques can be fetus specific. Tests currently available tend to not perform as well in multiple compared to singleton pregnancies. Considerations must be given to these variations when discussing and performing screening for aneuploidy in this situation. Prenatal invasive diagnosis techniques in multiple pregnancies bring their own challenges from a technical and counselling point of view, in particular with regards to sampling error, mapping and assignment of results and management of abnormal results. This review addresses these particular challenges and provides information to facilitate care. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：285 / 294

页数：10

共 80 条

[1] Pregnancy loss after chorionic villus sampling and genetic amniocentesis in twin pregnancies: a systematic review [J].

Agarwal, K. ;

Alfirevic, Z. .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2012, 40 (02) :128-134

[2] Pregnancy Outcomes After Assisted Reproductive Technology [J].

Allen, Victoria M. ;

Wilson, R. Douglas .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2006, 28 (03) :220-233

[3] Second-trimester amniocentesis vs. chorionic villus sampling for prenatal diagnosis in multiple gestations [J].

Antsaklis, A ;

Souka, AP ;

Daskalakis, G ;

Kavalakis, Y ;

Michalas, S .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2002, 20 (05) :476-481

[4] Invasive genetic diagnosis in multiple pregnancies [J].

Appelman, Z ;

Furman, B .

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2005, 32 (01) :97-+

[5]

BAHADOSINGH R, 1992, OBSTET GYNECOL, V79, P304

[6] Non-invasive prenatal testing for aneuploidy: current status and future prospects [J].

Benn, P. ;

Cuckle, H. ;

Pergament, E. .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2013, 42 (01) :15-33

[7] RANDOMIZED CLINICAL-TRIAL OF TRANSABDOMINAL VERSUS TRANSCERVICAL CHORIONIC VILLUS SAMPLING METHODS [J].

BRAMBATI, B ;

TERZIAN, E ;

TOGNONI, G .

PRENATAL DIAGNOSIS, 1991, 11 (05) :285-293

[8]

Brandenburg H, 1997, PRENATAL DIAG, V17, P281, DOI 10.1002/(SICI)1097-0223(199703)17:3<281::AID-PD57>3.0.CO

[9]

2-6

[10]

British Columbia Vital Statistics Agency, 2011, SEL VIT STAT HLTH ST, P53

← 1 2 3 4 5 6 7 8 →