VoltammetricDetermination of Glutathionein Pharmaceutical and Biological Samples Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Rutin as a Mediator

被引：2
作者：
Keyvanfard, Mohsen [1 ]
Jalilian, Zeynab [2 ]
Karimi-Maleh, Hassan [3 ]
Alizad, Khadijeh [1 ]
机构：
[1] Islamic Azad Univ, Majlesi Branch, Dept Chem, Esfahan, Iran
[2] Islamic Azad Univ, Shahreza Branch, Dept Chem, Esfahan, Iran
[3] Quchan Univ Technol, Lab Nanotechnol, Dept Chem Engn, Quchan, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2020年 / 19卷 / 02期
关键词：
Glutathione; Rutin; Multiwall carbon nanotubes; Modified electrode; Voltammetry; VOLTAMMETRIC DETERMINATION; IONIC LIQUID; ELECTROCATALYTIC DETERMINATION; FOLIC-ACID; DNA BIOSENSOR; SENSOR; NOREPINEPHRINE;
D O I：
10.22037/ijpr.2016.1947
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new sensitive and selective electrochemical sensor was developed for electrocatalytic determination of glutathione (GSH) in pharmaceutical and biological samples. GSH is a tripeptidethiol present in all eukaryotic and probiotic cells. A voltammetric study of GSH has been carried out at the surface of carbon paste electrode modified with multiwall carbon nanotubes in the presence of rutin as a mediator. The electrochemical oxidation of GSH was investigated by cyclic voltammetry, chronoamperometry and square wave voltammetry (SWV) techniques. Under the optimized conditions, the peak current was linear to GSH concentration over the concentration range of 0.3 to 180 mu mol L-1 using SWV. The detection limit was 0.09 mu mol L-1. The proposed method was successfully applied to the determination of GSH in the urine, tablet and hemolysed erythrocyte samples.
引用
收藏
页码：251 / 258
页数：8
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