MicroRNA and gynecological reproductive diseases

被引：100

作者：

Santamaria, Xavier ^{[1
]}

Taylor, Hugh ^{[2
]}

机构：

[1] Inst Valenciano Infertilidad IVI Barcelona, Dept Reprod Med, Barcelona, Spain

[2] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA

来源：

FERTILITY AND STERILITY | 2014年 / 101卷 / 06期

关键词：

MicroRNA; endometriosis; ovarian endometriosis; peritoneal endometriosis; single nucleotide polymorphisms; leiomyoma; recurrent pregnancy loss; RECURRENT SPONTANEOUS-ABORTION; GENE-EXPRESSION; HLA-G; DIFFERENTIAL EXPRESSION; PROGESTERONE RESISTANCE; OVARIAN-STEROIDS; ENDOMETRIOSIS; WOMEN; RISK; LEIOMYOMAS;

D O I：

10.1016/j.fertnstert.2014.04.044

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies. (C) 2014 by American Society for Reproductive Medicine.

引用

页码：1545 / 1551

页数：7

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