Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

被引：86

作者：

Chen, Huachao ^{[1
]}

Liu, Danyang ^{[1
]}

Guo, Zijian ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Coordionat Chem Inst, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHEMISTRY LETTERS | 2016年 / 45卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Drug delivery; Nanocarrier; Stimuli-responsive system; MESOPOROUS SILICA NANOPARTICLES; HUMAN SERUM-ALBUMIN; MULTIDRUG-RESISTANCE; CONTROLLED-RELEASE; CANCER-CELLS; OXIDATIVE STRESS; FOLATE RECEPTOR; CATHEPSIN-B; IN-VITRO; PH;

D O I：

10.1246/cl.151176

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug release in a spatially and temporally controlled manner is highly desired in the field of drug delivery. Endogenous stimuli responsive nanocarriers provide significant advantages in maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs. Biomarker-triggered release and site-specific delivery are the most commonly adopted strategies. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers and their potential application in the treatment of various diseases are highlighted and discussed.

引用

页码：242 / 249

页数：8

共 76 条

[1] Extracellularly activatable nanocarriers for drug delivery to tumors [J].

Abouelmagd, Sara A. ;

Hyun, Hyesun ;

Yeo, Yoon .

EXPERT OPINION ON DRUG DELIVERY, 2014, 11 (10) :1601-1618

[2] Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis [J].

Arias, Jose L. ;

Unciti-Broceta, Juan D. ;

Maceira, Jose ;

del Castillo, Teresa ;

Hernandez-Quero, Jose ;

Magez, Stefan ;

Soriano, Miguel ;

Garcia-Salcedo, Jose A. .

JOURNAL OF CONTROLLED RELEASE, 2015, 197 :190-198

[3] Polymer-Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery [J].

Aryal, Santosh ;

Hu, Che-Ming Jack ;

Zhang, Liangfang .

ACS NANO, 2010, 4 (01) :251-258

[4] pH and Redox Dual Responsive Nanoparticle for Nuclear Targeted Drug Delivery [J].

Bahadur, Remant K. C. ;

Thapa, Bindu ;

Xu, Peisheng .

MOLECULAR PHARMACEUTICS, 2012, 9 (09) :2719-2729

[5] Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [J].

Bartlett, Derek W. ;

Su, Helen ;

Hildebrandt, Isabel J. ;

Weber, Wolfgang A. ;

Davis, Mark E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15549-15554

[6]

Biswas S, 2013, NAT CHEM, V5, P613, DOI [10.1038/NCHEM.1681, 10.1038/nchem.1681]

[7] A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics [J].

Broaders, Kyle E. ;

Grandhe, Sirisha ;

Frechet, Jean M. J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (04) :756-758

[8] Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine [J].

Cabral, Horacio ;

Nishiyama, Nobuhiro ;

Kataoka, Kazunori .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :999-1008

[9] An H2O2-responsive nanocarrier for dual-release of platinum anticancer drugs and O2: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells [J].

Chen, Huachao ;

He, Weijiang ;

Guo, Zijian .

CHEMICAL COMMUNICATIONS, 2014, 50 (68) :9714-9717

[10] Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles [J].

Cheng, Qinqin ;

Shi, Hongdong ;

Huang, Hai ;

Cao, Zhiting ;

Wang, Jun ;

Liu, Yangzhong .

CHEMICAL COMMUNICATIONS, 2015, 51 (99) :17536-17539

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