Role of atrial endothelial cells in the development of atrial fibrosis and fibrillation in response to pressure overload

被引:19
作者
Kume, Osamu [1 ]
Teshima, Yasushi [1 ]
Abe, Ichitaro [1 ]
Ikebe, Yuki [1 ]
Oniki, Takahiro [1 ]
Kondo, Hidekazu [1 ]
Saito, Shotaro [1 ]
Fukui, Akira [1 ]
Yufu, Kunio [1 ]
Miura, Masahiro [2 ]
Shimada, Tatsuo [3 ]
Takahashi, Naohiko [1 ]
机构
[1] Oita Univ, Fac Med, Dept Cardiol & Clin Examinat, 1-1 Idaigaoka, Hasama, Oita 8795593, Japan
[2] Oita Univ, Fac Med, Dept Human Anat, Oita, Japan
[3] Oita Med Technol Sch, Coll Judo Therapy & Acupuncture Moxibust, Oita, Japan
关键词
Atrial fibrillation; Endothelium; Pressure overload; Inflammation; Fibrosis; OXIDATIVE STRESS; VASCULAR-DISEASE; ATHEROSCLEROSIS; PATHOGENESIS; INFLAMMATION; PROGRESSION; MECHANISMS; INITIATION; ANEURYSMS; SYSTEM;
D O I
10.1016/j.carpath.2016.12.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Monocyte chemoattractant protein-1 (MCP-1)-mediated inflammatory mechanisms have been shown to play a crucial role in atrial fibrosis induced by pressure overload. In the present study, we investigated whether left atrial endothelial cells would quickly respond structurally and functionally to pressure overload to trigger atrial fibrosis and fibrillation. Methods and results: Six-week-old male Sprague-Dawley rats underwent suprarenal abdominal aortic constriction (AAC) or a sham operation. By day 3 after surgery, macrophages were observed to infiltrate into the endocardium. The expression of MCP-1 and E-selectin in atrial endothelium and the expression of intercellular adhesion molecule-1, vascular cell adhesionmolecule-1, and ED1 in left atrial tissue were enhanced. Atrial endothelial cells were irregularly hypertrophied with the disarrangement of lines of cells by scanning electronmicroscopy. Various-sized gap formations appeared along the border in atrial endothelial cells, and several macrophages were located just in the endothelial gap. Along with the development of heterogeneous interstitial fibrosis, interatrial conduction time was prolonged and the inducibility of atrial fibrillation by programmed extrastimuli was increased in the AAC rats compared to the sham-operated rats. Conclusions: Atrial endothelium responds rapidly to pressure overload by expressing adhesion molecules and MCP-1, which induce macrophage infiltration into the atrial tissues. These processes could be an initial step in the development of atrial remodeling for atrial fibrillation. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:18 / 25
页数:8
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