A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia

被引：17
作者：
Li, Chao
Zheng, Yonglan
Qin, Wei
Tao, Ran
Pan, Yuxi
Xu, Yifeng
Li, Xingwang
Gu, Niufan
Feng, Guoyin
He, Lin
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
[2] Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, BioX Ctr, Shanghai 200030, Peoples R China
[4] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2006年 / 407卷 / 02期
基金：
中国国家自然科学基金;
关键词：
schizophrenia; KIF2; genetic polymorphisms; association study; Chinese population;
D O I：
10.1016/j.neulet.2006.08.025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Schizophrenia is a multifactorial disease characterized by multiple genetic susceptibility elements. The human KIF2 gene represents an orthologue of the murine Kif2a, which plays an important role in the transport of various membranous organelles and protein complexes on microtubules. To examine whether this gene is involved in schizophrenia etiology, we undertook studies of transmission disequilibrium in a cohort of affected family samples to test for association. Although, we failed to detect any positive results in single markers, a common two-SNP haplotype (rs2289883/rs464058, G/A) showed a significant association with the disease and a four-SNP haplotype (T/G/A/G) with a frequency of 23.4% was identified in parental chromosomes and showed a significant association with the disease (P = 0.00795). Our results demonstrate that the KIF2 gene, located at 5q12.1. is a potential schizophrenia susceptibility gene. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：151 / 155
页数：5
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