Rhenium(I) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

被引：21

作者：

Chan, Chung Ying ^{[1
]}

Noor, Asif ^{[2
,3
]}

McLean, Catriona A. ^{[4
]}

Donnelly, Paul S. ^{[2
,3
]}

Barnard, Peter J. ^{[1
]}

机构：

[1] La Trobe Univ, La Trobe Inst Mol Sci, Dept Chem & Phys, Bundoora, Vic 3086, Australia

[2] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3010, Australia

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 15期

基金：

澳大利亚研究理事会;

关键词：

HUMAN BIODISTRIBUTION; BETA; DOSIMETRY; SAFETY; SITES;

D O I：

10.1039/c6cc10066j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of [Re(I)L(CO)(3)](+) complexes (where L is a bifunctional bis(NHC)- amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

引用

页码：2311 / 2314

页数：4

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