Honey-Loaded Reinforced Film Based on Bacterial Nanocellulose/Gelatin/Guar Gum as an Effective Antibacterial Wound Dressing

Recently, the use of bacterial nanocellulose (BNC) produced by Acetobacter, which has suitable properties for tissue engineering application as a perfect wound dressing, has attracted considerable attention. For this purpose, we success-fully developed honey loaded BNC-reinforced gelatin/dialdehyde-modified guar gum films (H/BNC/Ge/D-GG). Prepared films were studied for their morIP:phological,8.46ther247.10mal On:stability,Wed, 04mechanicl,Jan 2023water solubility06:12:02and degradability properties. The physicochemical properties of the developed films with or without honey loading were studied. The results indicated that Copyright: American Scientific Publishers by enhancing the honey content of the film, the degradation behavior, adhesion and proliferation of NIH-3T3 fibroblast Delivered by Ingenta cells were improved. The films with 15 wt% of honey revealed inhibition activity against S. aureus (13.0 +/- 0.1 mm) and E. coli (15.0 +/- 1.0 mm) bacteria. Cell culture results demonstrated that the prepared films had good cytocompatibility. Based on the results, the prepared H/BNC/Ge/D-GG films appear to have high potential for antibacterial wound dressings.