The number and diversity of techniques to create well-defined polymeric architectures has set the foundation to reinvent macromolecular chemistry's tenor. This development offers the chance to build refined structures with multifaceted, cross-disciplinary applications. We discuss a few advances in the design and development of selected nanoobjects with far-reaching potential. Herein, well-defined building blocks and introduced methods to establish three-dimensional architectures will be presented. Sequential attachment strategies and tools taken from biological chemistries achieve new levels of specificity.