Ocrelizumab in multiple sclerosis: markers and mechanisms

被引:14
作者
Hohlfeld, Reinhard [1 ,2 ,3 ]
Meinl, Edgar [1 ,2 ,3 ]
机构
[1] Ludwig Maximilians Univ Munchen, Inst Clin Neuroimmunol, Univ Hosp, Munich, Germany
[2] Ludwig Maximilians Univ Munchen, Biomed Ctr, Munich, Germany
[3] Munich Cluster Syst Neurol SyNergy, Munich, Germany
关键词
T-CELLS; B-CELLS; RITUXIMAB; ANTIBODIES;
D O I
10.1016/S1474-4422(17)30048-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:259 / 261
页数:4
相关论文
共 12 条
[1]   Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins [J].
Braendle, Simone M. ;
Obermeier, Birgit ;
Senel, Makbule ;
Bruder, Jessica ;
Mentele, Reinhard ;
Khademi, Mohsen ;
Olsson, Tomas ;
Tumani, Hayrettin ;
Kristoferitsch, Wolfgang ;
Lottspeich, Friedrich ;
Wekerle, Hartmut ;
Hohlfeld, Reinhard ;
Dornmair, Klaus .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7864-7869
[2]   Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients [J].
Cross, Anne H. ;
Stark, Jennifer L. ;
Lauber, Joanne ;
Ramsbottom, Michael J. ;
Lyons, Jeri-Anne .
JOURNAL OF NEUROIMMUNOLOGY, 2006, 180 (1-2) :63-70
[3]   Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease [J].
Flach, Anne-Christine ;
Litke, Tanja ;
Strauss, Judith ;
Haberl, Michael ;
Gomez, Cesar Cordero ;
Reindl, Markus ;
Saiz, Albert ;
Fehling, Hans-Joerg ;
Wienands, Juergen ;
Odoardi, Francesca ;
Luehder, Fred ;
Fluegel, Alexander .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (12) :3323-3328
[4]   Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis [J].
Hauser, S. L. ;
Bar-Or, A. ;
Comi, G. ;
Giovannoni, G. ;
Hartung, H. -P. ;
Hemmer, B. ;
Lublin, F. ;
Montalban, X. ;
Rammohan, K. W. ;
Selmaj, K. ;
Traboulsee, A. ;
Wolinsky, J. S. ;
Arnold, D. L. ;
Klingelschmitt, G. ;
Masterman, D. ;
Fontoura, P. ;
Belachew, S. ;
Chin, P. ;
Mairon, N. ;
Garren, H. ;
Kappos, L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (03) :221-234
[5]   The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity [J].
Hoffmann, Franziska S. ;
Kuhn, Peer-Hendrik ;
Laurent, Sarah A. ;
Hauck, Stefanie M. ;
Berer, Kerstin ;
Wendlinger, Simone A. ;
Krumbholz, Markus ;
Khademi, Mohsen ;
Olsson, Tomas ;
Dreyling, Martin ;
Pfister, Hans-Walter ;
Alexander, Tobias ;
Hiepe, Falk ;
Kuempfel, Tania ;
Crawford, Howard C. ;
Wekerle, Hartmut ;
Hohlfeld, Reinhard ;
Lichtenthaler, Stefan F. ;
Meinl, Edgar .
JOURNAL OF IMMUNOLOGY, 2015, 194 (02) :542-552
[6]   The search for the target antigens of multiple sclerosis, part 2: CD8+T cells, B cells, and antibodies in the focus of reverse-translational research [J].
Hohlfeld, Reinhard ;
Dornmair, Klaus ;
Meinl, Edgar ;
Wekerle, Hartmut .
LANCET NEUROLOGY, 2016, 15 (03) :317-331
[7]   Insufficient disease inhibition by intrathecal rituximab in progressive multiple sclerosis [J].
Komori, Mika ;
Lin, Yen Chih ;
Cortese, Irene ;
Blake, Andrew ;
Ohayon, Joan ;
Cherup, Jamie ;
Maric, Dragan ;
Kosa, Peter ;
Wu, Tianxia ;
Bielekova, Bibiana .
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2016, 3 (03) :166-179
[8]   γ-secretase directly sheds the survival receptor BCMA from plasma cells [J].
Laurent, Sarah A. ;
Hoffmann, Franziska S. ;
Kuhn, Peer-Hendrik ;
Cheng, Qingyu ;
Chu, Yuanyuan ;
Schmidt-Supprian, Marc ;
Hauck, Stefanie M. ;
Schuh, Elisabeth ;
Krumbholz, Markus ;
Ruebsamen, Heike ;
Wanngren, Johanna ;
Khademi, Mohsen ;
Olsson, Tomas ;
Alexander, Tobias ;
Hiepe, Falk ;
Pfister, Hans-Walter ;
Weber, Frank ;
Jenne, Dieter ;
Wekerle, Hartmut ;
Hohlfeld, Reinhard ;
Lichtenthaler, Stefan F. ;
Meinl, Edgar .
NATURE COMMUNICATIONS, 2015, 6
[9]   Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy [J].
Li, Rui ;
Rezk, Ayman ;
Miyazaki, Yusei ;
Hilgenberg, Ellen ;
Touil, Hanane ;
Shen, Ping ;
Moore, Craig S. ;
Michel, Laure ;
Althekair, Faisal ;
Rajasekharan, Sathy ;
Gommerman, Jennifer L. ;
Prat, Alexandre ;
Fillatreau, Simon ;
Bar-Or, Amit .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (310)
[10]   Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis [J].
Montalban, X. ;
Hauser, S. L. ;
Kappos, L. ;
Arnold, D. L. ;
Bar-Or, A. ;
Comi, G. ;
de Seze, J. ;
Giovannoni, G. ;
Hartung, H. -P. ;
Hemmer, B. ;
Lublin, F. ;
Rammohan, K. W. ;
Selmaj, K. ;
Traboulsee, A. ;
Sauter, A. ;
Masterman, D. ;
Fontoura, P. ;
Belachew, S. ;
Garren, H. ;
Mairon, N. ;
Chin, P. ;
Wolinsky, J. S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (03) :209-220