IL-17-producing γδ T cells

被引：128
|
作者：
O'Brien, Rebecca L. [1 ]
Roark, Christina L. [1 ]
Born, Willi K. [1 ]
机构：
[1] Univ Colorado, Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 03期
关键词：
gamma delta T cells; Autoimmunity; IL-17; Immunodeficiency; Infection; ESCHERICHIA-COLI INFECTION; IL-17; PRODUCTION; NEUTROPHILS; T(H)17; INNATE; PLAYS; LUNG;
D O I：
10.1002/eji.200839120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-17 is produced not only by CD4(+) alpha beta T cells, but also CD8(+) alpha beta T cells, NKT cells, and gamma delta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gamma delta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
引用
收藏
页码：662 / 666
页数：5
相关论文
共 50 条
  • [21] HEB is required for the specification of fetal IL-17-producing γδ T cells
    In, Tracy S. H.
    Trotman-Grant, Ashton
    Fahl, Shawn
    Chen, Edward L. Y.
    Zarin, Payam
    Moore, Amanda J.
    Wiest, David L.
    Zuniga-Pflucker, Juan Carlos
    Anderson, Michele K.
    NATURE COMMUNICATIONS, 2017, 8
  • [22] HEB is required for the specification of fetal IL-17-producing γδ T cells
    Tracy S. H. In
    Ashton Trotman-Grant
    Shawn Fahl
    Edward L. Y. Chen
    Payam Zarin
    Amanda J. Moore
    David L. Wiest
    Juan Carlos Zúñiga-Pflücker
    Michele K. Anderson
    Nature Communications, 8
  • [23] Contribution of IL-17-producing γδ T cells to the efficacy of anticancer chemotherapy
    Ma, Yuting
    Aymeric, Laetitia
    Locher, Clara
    Mattarollo, Stephen R.
    Delahaye, Nicolas F.
    Pereira, Pablo
    Boucontet, Laurent
    Apetoh, Lionel
    Ghiringhelli, Francois
    Casares, Noelia
    Lasarte, Juan Jose
    Matsuzaki, Goro
    Ikuta, Koichi
    Ryffel, Bernard
    Benlagha, Kamel
    Tesniere, Antoine
    Ibrahim, Nicolas
    Dechanet-Merville, Julie
    Chaput, Nathalie
    Smyth, Mark J.
    Kroemer, Guido
    Zitvogel, Laurence
    JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (03): : 491 - 503
  • [24] IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells
    Corpuz, Theresa M.
    Vazquez-Lombardi, Rodrigo
    Luong, Jason K.
    Warren, Joanna
    Stolp, Jessica
    Christ, Daniel
    King, Cecile
    Brink, Robert
    Sprent, Jonathan
    Webster, Kylie E.
    JOURNAL OF IMMUNOLOGY, 2017, 199 (07): : 2366 - 2376
  • [25] Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation
    Cai, Yihua
    Shen, Xiaoyan
    Ding, Chuanlin
    Qi, Chunjian
    Li, Kejia
    Li, Xia
    Jala, Venkatakrishna R.
    Zhang, Huang-ge
    Wang, Tian
    Zheng, Jie
    Yan, Jun
    IMMUNITY, 2011, 35 (04) : 596 - 610
  • [26] The Role of T Helper 17 Cells and Other IL-17-Producing Cells in Bone Resorption and Remodeling
    Liu, Wen-Xing
    Li, Zhi-Jun
    Niu, Xiu-Long
    Yao, Zhi
    Deng, Wei-Min
    INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2015, 34 (04) : 332 - 347
  • [27] IL-17-producing B cells combat parasites
    Leon, Beatriz
    Lund, Frances E.
    NATURE IMMUNOLOGY, 2013, 14 (05) : 419 - 421
  • [28] IL-17 and IL-17-producing cells in protection versus pathology
    Kingston H. G. Mills
    Nature Reviews Immunology, 2023, 23 : 38 - 54
  • [29] IL-17 and IL-17-producing cells in protection versus pathology
    Mills, Kingston H. G.
    NATURE REVIEWS IMMUNOLOGY, 2023, 23 (01) : 38 - 54
  • [30] IL-17-producing γδ T cells protect against Clostridium difficile infection
    Chen, Yee-Shiuan
    Chen, Iuan-Bor
    Pham, Giang
    Shao, Tzu-Yu
    Bangar, Hansraj
    Way, Sing Sing
    Haslam, David B.
    JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05): : 2377 - 2390
12345