IL-17-producing γδ T cells

被引：128
|
作者：
O'Brien, Rebecca L. [1 ]
Roark, Christina L. [1 ]
Born, Willi K. [1 ]
机构：
[1] Univ Colorado, Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 03期
关键词：
gamma delta T cells; Autoimmunity; IL-17; Immunodeficiency; Infection; ESCHERICHIA-COLI INFECTION; IL-17; PRODUCTION; NEUTROPHILS; T(H)17; INNATE; PLAYS; LUNG;
D O I：
10.1002/eji.200839120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-17 is produced not only by CD4(+) alpha beta T cells, but also CD8(+) alpha beta T cells, NKT cells, and gamma delta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gamma delta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
引用
收藏
页码：662 / 666
页数：5
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