IL-17-producing γδ T cells

被引：128
|
作者：
O'Brien, Rebecca L. [1 ]
Roark, Christina L. [1 ]
Born, Willi K. [1 ]
机构：
[1] Univ Colorado, Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 03期
关键词：
gamma delta T cells; Autoimmunity; IL-17; Immunodeficiency; Infection; ESCHERICHIA-COLI INFECTION; IL-17; PRODUCTION; NEUTROPHILS; T(H)17; INNATE; PLAYS; LUNG;
D O I：
10.1002/eji.200839120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-17 is produced not only by CD4(+) alpha beta T cells, but also CD8(+) alpha beta T cells, NKT cells, and gamma delta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gamma delta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
引用
收藏
页码：662 / 666
页数：5
相关论文
共 50 条
  • [1] Characteristics of IL-17-Producing γδ T Cells
    O'Brien, Rebecca
    Jin, Niyun
    Huang, Yafei
    Aydintug, M. Kemal
    Roark, Christina
    Born, Willi
    IMMUNITY, 2010, 32 (01) : 1 - 1
  • [2] How to develop IL-17-producing γδ T cells
    Fiala, Gina J.
    Silva-Santos, Bruno
    IMMUNOLOGY AND CELL BIOLOGY, 2018, 96 (09): : 886 - 887
  • [3] Characteristics of IL-17-Producing γδ T Cells Response
    Veldhoen, Marc
    Stockinger, Brigitta
    IMMUNITY, 2010, 32 (01) : 2 - 2
  • [4] IL-17-producing T cells in lupus nephritis
    Apostolidis, S. A.
    Crispin, J. C.
    Tsokos, G. C.
    LUPUS, 2011, 20 (02) : 120 - 124
  • [5] IL-17-producing γδ T cells and innate lymphoid cells
    Sutton, Caroline E.
    Mielke, Lisa A.
    Mills, Kingston H. G.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (09) : 2221 - 2231
  • [6] IL-17-producing γδ T cells enhance bone regeneration
    Takehito Ono
    Kazuo Okamoto
    Tomoki Nakashima
    Takeshi Nitta
    Shohei Hori
    Yoichiro Iwakura
    Hiroshi Takayanagi
    Nature Communications, 7
  • [7] Induction, function and regulation of IL-17-producing T cells
    Mills, Kingston H. G.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (10) : 2636 - 2649
  • [8] Embryonic thymus required for IL-17-producing γδ T cells
    Kirsty Minton
    Nature Reviews Immunology, 2012, 12 (8) : 550 - 550
  • [9] IL-17-producing γδ T cells enhance bone regeneration
    Ono, Takehito
    Okamoto, Kazuo
    Nakashima, Tomoki
    Nitta, Takeshi
    Hori, Shohei
    Iwakura, Yoichiro
    Takayanagi, Hiroshi
    NATURE COMMUNICATIONS, 2016, 7
  • [10] IL-17-producing T cells in lung immunity and inflammation
    Nembrini, Chiara
    Marsland, Benjamin J.
    Kopf, Manfred
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (05) : 986 - 994
12345