Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome

被引：20

作者：

Balint, Anita ^{[1
]}

Farkas, Klaudia ^{[1
]}

Mehi, Orsolya ^{[2
]}

Kintses, Balint ^{[2
,6
,7
]}

Vasarhelyi, Balint Mark ^{[2
]}

Ari, Eszter ^{[2
,3
,8
]}

Pal, Csaba ^{[2
]}

Madacsy, Tamara ^{[1
,4
]}

Maleth, Jozsef ^{[1
,4
]}

Szanto, Kata Judit ^{[1
]}

Nagy, Istvan ^{[5
]}

Rutka, Mariann ^{[1
]}

Bacsur, Peter ^{[1
]}

Szucs, Diana ^{[1
,4
]}

Szepes, Zoltan ^{[1
]}

Nagy, Ferenc ^{[1
]}

Fabian, Anna ^{[1
]}

Bor, Renata ^{[1
]}

Milassin, Agnes ^{[1
]}

Molnar, Tamas ^{[1
]}

机构：

[1] Univ Szeged, Dept Med, H-6720 Szeged, Hungary

[2] Biol Res Ctr, Inst Biochem, Synthet & Syst Biol Unit, H-6726 Szeged, Hungary

[3] Eotvos Lorand Univ, Dept Genet, H-1053 Budapest, Hungary

[4] Univ Szeged, Hungarian Acad Sci, Dept Med, Momentum Epithelial Signalizat & Secret Workgrp, H-1051 Szeged, Hungary

[5] Biol Res Ctr, Inst Biochem, Sequencing Platform, H-6726 Szeged, Hungary

[6] HCEMM BRC Translat Microbiol Lab, H-6726 Szeged, Hungary

[7] Univ Szeged, Dept Biochem & Mol Biol, H-6720 Szeged, Hungary

[8] HCEMM BRC Metab Syst Biol Lab, H-6726 Szeged, Hungary

来源：

PHARMACEUTICALS | 2020年 / 13卷 / 11期

关键词：

gut microbiome; faecal microbiome; ulcerative colitis; pouch; familial adenomatous polyposis; functional anatomical changes; ILEAL-POUCH; INFLAMMATION; COMMUNITY; PROFILES;

D O I：

10.3390/ph13110346

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gut microbial composition alters in some special situations, such as in ulcerative colits (UC) after total proctocolectomy and ileal pouch-anal anastomosis (IPAA) surgery. The aim of our study was to determine the composition of the intestinal microbiome in UC patients after IPAA surgery, compared with UC patients, familial adenomatous polyposis (FAP) patients after IPAA surgery and healthy controls. Clinical data of patients, blood and faecal samples were collected. Faecal microbiota structure was determined by sequencing the V4 hypervariable region of the 16S rRNA gene. Overall, 56 patients were enrolled. Compared to the Healthy group, both the Pouch active and UC active groups had higher Enterobacteriaceae, Enterococcaceae and Pasteurellaceae abundance. The Pouch and UC groups showed distinct separation based on their alpha and beta bacterial diversities. The UC group had higher Prevotellaceae, Rikenellaceae, Ruminococcaceae abundance compared to the Pouch active group. Pouch and FAP participants showed similar bacterial community composition. There was no significant difference in the bacterial abundance between the active and inactive subgroups of the Pouch or UC groups. Gut microbiome and anatomical status together construct a functional unit that has influence on diversity, in addition to intestinal inflammation that is a part of the pathomechanism in UC.

引用

页码：1 / 16

页数：16

共 41 条

[1] Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis [J].