Enantiodivergent synthesis of 2-hydroxymethyl-3-hydroxy-4-nitro-pyrrolidines through tandem Michael-Henry reaction using L-serine as the chiral educt.

被引：29

作者：

Barco, A ^{[1
]}

Benetti, S ^{[1
]}

DeRisi, C ^{[1
]}

Pollini, GP ^{[1
]}

Romagnoli, R ^{[1
]}

Zanirato, V ^{[1
]}

机构：

[1] DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

关键词：

D O I：

10.1016/0040-4039(96)01671-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By utilizing L-serine, both enantiomers of all trans a-hydroxymethyl 3-hydroxy-4-nitro-pyrrolidine were efficiently prepared through tandem Michael-Henry methodology. Their stereochemistry has been assigned through conversion of one of them to trans 2-hydroxymethyl-3-hydroxypyrrolidine, a naturally occurring compound recently isolated from Castanospermum australe. Copyright (C) 1996 Elsevier Science Ltd

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页码：7599 / 7602

页数：4

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