MDA5 and LGP2: Accomplices and Antagonists of Antiviral Signal Transduction

被引：96

作者：

Rodriguez, Kenny R. ^{[1
]}

Bruns, Annie M. ^{[1
]}

Horvath, Curt M. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Mol Biosci, Evanston, IL 60208 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 15期

关键词：

DOUBLE-STRANDED-RNA; I-LIKE RECEPTORS; INDUCIBLE GENE-I; PARAMYXOVIRUS V-PROTEINS; INNATE IMMUNE-RESPONSES; IFN-BETA PROMOTER; NF-KAPPA-B; RIG-I; STRUCTURAL BASIS; HELICASE LGP2;

D O I：

10.1128/JVI.00640-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mammalian cells have the ability to recognize virus infection and mount a powerful antiviral transcriptional response that provides an initial barrier to replication and impacts both innate and adaptive immune responses. Retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) proteins mediate intracellular virus recognition and are activated by viral RNA ligands to induce antiviral signal transduction. While the mechanisms of RIG-I regulation are already well understood, less is known about the more enigmatic melanoma differentiation-associated 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2). Emerging evidence suggests that these two RLRs are intimately associated as both accomplices and antagonists of antiviral signal transduction.

引用

页码：8194 / 8200

页数：7

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