Apelin/APJ signaling in hypoxia-related diseases

被引：51

作者：

He, Lu ^{[1
]}

Xu, Jin ^{[1
]}

Chen, Linxi ^{[1
]}

Li, Lanfang ^{[1
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2015年 / 451卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Apelin/APJ; Hypoxia/hypoxia-inducible factor-1 alpha; Hypoxia-related diseases; ENDOTHELIAL GROWTH-FACTOR; RETINAL MULLER CELLS; PULMONARY-HYPERTENSION; TRANSDUCTION PATHWAY; VASCULAR DEVELOPMENT; ENDOGENOUS LIGAND; ANGIOGENIC FACTOR; ADIPOSE-TISSUE; FACTOR; 1-ALPHA; APJ RECEPTOR;

D O I：

10.1016/j.cca.2015.09.029

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The regulatory peptide apelin is the endogenous ligand for the orphan G protein-coupled receptor APJ. Apelin and APJ exist in a variety of tissues, with special status in the heart, lung and tumors. Consequently, the apelin/APJ system exerts a broad range of activities that affect multiple organ systems. Accumulating evidence indicates that the expressions of apelin and APJ are significantly augmented by hypoxia through the hypoxia-inducible factor-1 alpha (HIF-l alpha.) signaling pathway. Increased apelin promotes cellular proliferation, migration and survival, therefore regulating angiogenesis. In addition, the pre-administration of exogenous apelin is involved in the occurrence and development of hypoxia-induced pathological diseases. The purpose of this article is to review the properties of the apelin/APJ system, which is affected by hypoxic conditions, and the regulation of apelin/APJ signaling in hypoxia-associated disorders. Thus, the apelin/APJ system may be a potential therapeutic target in hypoxia-related diseases. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：191 / 198

页数：8

共 92 条

[1] Pulmonary apelin levels and effects in rats with hypoxic pulmonary hypertension [J].