Rivaroxaban With or Without Aspirin for the Secondary Prevention of Cardiovascular Disease: Clinical Implications of the COMPASS Trial

被引：5

作者：

Nicholls, Stephen J. ^{[1
,2
]}

Nelson, Adam J. ^{[1
]}

机构：

[1] South Australian Hlth & Med Res Inst, POB 11060, Adelaide, SA 5001, Australia

[2] Monash Univ, Monash Cardiovasc Res Ctr, Melbourne, Vic, Australia

来源：

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS | 2019年 / 19卷 / 04期

关键词：

ACUTE CORONARY SYNDROMES; DUAL ANTIPLATELET THERAPY; ACUTE MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEIN CHOLESTEROL; DOUBLE-BLIND; ARTERY-DISEASE; ATRIAL-FIBRILLATION; STATIN THERAPY; LONG-TERM; CLOPIDOGREL;

D O I：

10.1007/s40256-018-00322-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The COMPASS trial compared the impact of the selective direct factor Xa inhibitor, rivaroxaban, as monotherapy or in combination with aspirin on major adverse cardiovascular events (MACE) in patients with stable atherosclerotic disease. Patients treated with rivaroxaban 2.5mg twice daily in combination with aspirin experienced fewer cardiovascular events but more bleeding complications than those who received aspirin monotherapy. In contrast, a higher dose of rivaroxaban (5mg twice daily) and aspirin produced no clinical benefit and continued to be associated with greater bleeding rates than aspirin. Examining this study in the context of other trials of anticoagulant therapy in atherosclerotic vascular disease, this review attempts to place the role of very low-dose rivaroxaban in clinical context and highlights areas for future research.

引用

页码：343 / 348

页数：6

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