Pd-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles

被引：133

作者：

Zhao, Mi-Na ^{[1
]}

Ren, Zhi-Hui ^{[1
]}

Wang, Yao-Yu ^{[1
]}

Guan, Zheng-Hui ^{[1
]}

机构：

[1] NW Univ Xian, Dept Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; POLYSUBSTITUTED PYRROLES; INTRAMOLECULAR ADDITION; EFFICIENT SYNTHESIS; TERTIARY ENAMIDES; TERMINAL ALKYNES; RUTHENIUM; CYCLOADDITION; ACTIVATION; INDOLES;

D O I：

10.1021/ol403517p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient palladium(II)-catalyzed alkenyl C-H activation oxidative annulation of enamides with alkynes for the synthesis of substituted pyrroles has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the synthesis of triaryl-substituted pyrroles in high yields.

引用

页码：608 / 611

页数：4

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