Use of Hydroxocobalamin (Vitamin B12a) in Patients With Vasopressor Refractory Hypotension After Cardiopulmonary Bypass: A Case Series

被引：24

作者：

Armour, Sarah ^{[1
]}

Armour, Trygve K. ^{[1
]}

Joppa, William R. ^{[2
]}

Maltais, Simon ^{[3
]}

Nelson, James A. ^{[1
]}

Wittwer, Erica ^{[1
]}

机构：

[1] Mayo Clin, Coll Med & Sci, Dept Anesthesiol & Perioperat Med, 200 First St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med & Sci, Cardiovasc ICU, Rochester, MN USA

[3] Mayo Clin, Coll Med & Sci, Dept Cardiovasc Surg, Rochester, MN USA

来源：

ANESTHESIA AND ANALGESIA | 2019年 / 129卷 / 01期

关键词：

HIGH-DOSE HYDROXOCOBALAMIN; VASOPLEGIC SYNDROME; METHYLENE-BLUE; NITRIC-OXIDE;

D O I：

10.1213/ANE.0000000000003648

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Hydroxocobalamin (vitamin B12a) is an emerging treatment for vasoplegic syndrome (VS) associated with cardiopulmonary bypass (CPB). Given its cost and scarcity, an institutional guideline for its use as a rescue treatment in cases of suspected VS was developed. Hemodynamic variables and vasopressor requirements were reviewed for a series of 24 post-CPB patients who received B12a. Favorable changes in hemodynamic parameters and vasopressor requirements were seen after B12a administration although guideline criteria for VS were inconsistently met. These findings support the continued study of B12a in patients with CPB-associated VS.

引用

页码：E1 / E4

页数：4

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