Inflammation-coagulation network: are serine protease receptors the knot?

被引：86

作者：

Cirino, G

Napoli, C

Bucci, M

Cicala, C

机构：

[1] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[2] Univ Calif San Diego, Dept Med 0682, La Jolla, CA 92093 USA

[3] Univ Sassari, Dept Pharmacol, I-07100 Sassari, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 05期

关键词：

D O I：

10.1016/S0165-6147(00)01469-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following an injury, the body recruits a mechanism to delimit and repair tissue damage; this phenomenon is known as inflammation. Among the several different pathways that are activated during this process, which is necessary for survival, activation of the coagulation pathway is a key feature. In fact, clinical changes in blood fluidity have been closely related to ongoing inflammation. Recent evidence suggests that serine protease receptors might play a major role in the host defence mechanism at the interface between coagulation and inflammation.

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页码：170 / 172

页数：3

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