Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly

被引:20
作者
Jeong, Dae Gwin [2 ]
Jung, Suk-Kyeong [2 ]
Yoon, Tae-Sung [2 ]
Woo, Eui-Jeon [2 ]
Kim, Jae Hoon [3 ]
Park, Byoung Chul [2 ]
Ryu, Seong Eon [1 ,4 ]
Kim, Seung Jun [2 ]
机构
[1] Korea Res Inst Biosci & Biotechnol, System Prote Res Ctr, Taejon 305333, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Med Prote Res Ctr, Taejon 305333, South Korea
[3] Jeju Natl Univ, Fac Biotechnol, Coll Appl Life Sci, Cheju 690756, South Korea
[4] Hanyang Univ, Dept Bio Engn, Seoul 133791, South Korea
关键词
protein tyrosine phosphatase; MKP-2; crystal structure; MAP KINASE PHOSPHATASE-2; PROTEIN; ERK2; INHIBITION; EXPRESSION; BINDING; PRL-1;
D O I
10.1002/prot.22423
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:763 / 767
页数:5
相关论文
共 27 条
  • [1] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY
    BAILEY, S
    [J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 : 760 - 763
  • [2] Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization
    Bilwes, AM
    denHertog, J
    Hunter, T
    Noel, JP
    [J]. NATURE, 1996, 382 (6591) : 555 - 559
  • [3] Crystallography & NMR system:: A new software suite for macromolecular structure determination
    Brunger, AT
    Adams, PD
    Clore, GM
    DeLano, WL
    Gros, P
    Grosse-Kunstleve, RW
    Jiang, JS
    Kuszewski, J
    Nilges, M
    Pannu, NS
    Read, RJ
    Rice, LM
    Simonson, T
    Warren, GL
    [J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 : 905 - 921
  • [4] Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase
    Cadalbert, L
    Sloss, CM
    Cameron, P
    Plevin, R
    [J]. CELLULAR SIGNALLING, 2005, 17 (10) : 1254 - 1264
  • [5] Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
    Camps, M
    Nichols, A
    Gillieron, C
    Antonsson, B
    Muda, M
    Chabert, C
    Boschert, U
    Arkinstall, S
    [J]. SCIENCE, 1998, 280 (5367) : 1262 - 1265
  • [6] Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically
    Chen, PL
    Hutter, D
    Yang, XL
    Gorospe, M
    Davis, RJ
    Liu, YS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) : 29440 - 29449
  • [7] The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
    Chu, YF
    Solski, PA
    KhosraviFar, R
    Der, CJ
    Kelly, K
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (11) : 6497 - 6501
  • [8] Structure and regulation of MAPK phosphatases
    Farooq, A
    Zhou, MM
    [J]. CELLULAR SIGNALLING, 2004, 16 (07) : 769 - 779
  • [9] PROTEIN-STRUCTURE COMPARISON BY ALIGNMENT OF DISTANCE MATRICES
    HOLM, L
    SANDER, C
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1993, 233 (01) : 123 - 138
  • [10] Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase
    Jeong, Dae Gwin
    Cho, Yoon Hea
    Yoon, Tae-Sung
    Kim, Jae Hoon
    Ryu, Seong Eon
    Kim, Seung Jun
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2007, 66 (01) : 253 - 258