The Link Between Obstructive Sleep Apnea and Cardiovascular Disease

被引：103
作者：
Bauters, Fre [1 ]
Rietzschel, Ernst R. [1 ]
Hertegonne, Katrien B. C. [1 ]
Chirinos, Julio A. [1 ,2 ]
机构：
[1] Ghent Univ Hosp, Ghent, Belgium
[2] Hosp Univ Penn, 3400 Spruce St Gates 9021, Philadelphia, PA 19060 USA
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2016年 / 18卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Obstructive sleep apnea; Cardiovascular disease; Continuous positive airway pressure; Hypertension; Obesity; Inflammation; POSITIVE AIRWAY PRESSURE; ATRIAL-FIBRILLATION RECURRENCE; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; INDEPENDENT RISK-FACTOR; CHRONIC HEART-FAILURE; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE;
D O I：
10.1007/s11883-015-0556-z
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Obstructive sleep apnea (OSA) is common in the general population and highly prevalent in patients with cardiovascular disease. In this paper, we review (1) the pathophysiological mechanisms of OSA that may causally contribute to cardiovascular disease; (2) current evidence regarding the association between OSA and hypertension, stroke, ischemic heart disease, heart failure, atrial fibrillation, and cardiovascular mortality; and (3) the impact of continuous positive airway pressure (CPAP) treatment on cardiovascular risk factors and outcomes. We emphasize the importance of obesity as a comorbidity of OSA and a confounder in the association between OSA and cardiovascular disease. We also discuss the importance of addressing obesity in patients with OSA, as a strategy to reduce the burden of cardiovascular risk factors in this population. Implications for the approach of patients' OSA in clinical practice and future research directions are discussed.
引用
收藏
页码：1 / 11
页数：11
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