N-Pyrrylarylsulfones with High Therapeutic Potential

被引：7
作者：
Famiglini, Valeria [1 ]
Castellano, Sabrina [2 ]
Silvestri, Romano [1 ]
机构：
[1] Sapienza Univ Rome, Dept Drug Chem & Technol, Lab Ist Pasteur Italia Fdn Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[2] Univ Salerno, Dept Pharm, Via Giovanni Paolo II 132, I-84084 Salerno, Italy
来源：
MOLECULES | 2017年 / 22卷 / 03期
关键词：
sulfonamide; heterocycle; polycyclic compound; therapeutic agent; REVERSE-TRANSCRIPTASE INHIBITORS; INDOLYL ARYL SULFONES; BENZOTHIADIAZEPINE MOIETY; BIOLOGICAL EVALUATION; NONNUCLEOSIDE INHIBITOR; SELECTIVE-INHIBITION; SMILES REARRANGEMENT; CHEMICAL FORMULAS; WILD-TYPE; DERIVATIVES;
D O I：
10.3390/molecules22030434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.
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页数：18
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