FOXO3a knockdown promotes radioresistance in nasopharyngeal carcinoma by inducing epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway

被引：56

作者：

Luo, Min ^{[2
]}

Wu, Cheng ^{[1
]}

Guo, Ergang ^{[1
]}

Peng, Shan ^{[2
]}

Zhang, Linli ^{[1
]}

Sun, Wei ^{[1
]}

Liu, Dongbo ^{[1
]}

Hu, Guangyuan ^{[1
]}

Hu, Guoqing ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, 1095 Jiefang Rd, Wuhan 430030, Hubei, Peoples R China

[2] Wuhan Univ, Dept Radiat & Med Oncol, Zhongnan Hosp, Wuhan, Hubei, Peoples R China

来源：

CANCER LETTERS | 2019年 / 455卷

基金：

中国国家自然科学基金;

关键词：

NPC; FOXO3a; Radioresistance; Epithelial-mesenchymal transition; Wnt; EPSTEIN-BARR-VIRUS; BETA-CATENIN; CELLS; SUPPRESSES; RESISTANCE; APOPTOSIS; AUTOPHAGY; PROLIFERATION; CONTRIBUTES; METASTASIS;

D O I：

10.1016/j.canlet.2019.04.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in the forkhead box O 3a (FOXO3a) gene are closely related to the progression of several types of cancers. However, few studies explore the relationship between FOXO3a and nasopharyngeal carcinoma (NPC). Our findings demonstrate that silencing FOXO3a promotes tumor radioresistance of NPC in vitro and in vivo through inducing EMT and activating Wnt/beta-catenin signal pathway. These data establish that FOXO3a can be a novel and reliable NPC marker and a potential therapeutic target against NPC.

引用

页码：26 / 35

页数：10

共 49 条

[1] Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation [J].

Chen, Albert Tzong-Yang ;

Guo, Chunfang ;

Dumas, Kathleen J. ;

Ashrafi, Kaveh ;

Hu, Patrick J. .

AGING CELL, 2013, 12 (05) :932-940

[2] Nasopharyngeal carcinoma [J].

Chua, Melvin L. K. ;

Wee, Joseph T. S. ;

Hui, Edwin P. ;

Chan, Anthony T. C. .

LANCET, 2016, 387 (10022) :1012-1024

[3] β-catenin as a potential key target for tumor suppression [J].

Fu, Yuejun ;

Zheng, Shuhua ;

An, Na ;

Athanasopoulos, Takis ;

Popplewell, Linda ;

Liang, Aihua ;

Li, Ke ;

Hu, Changchen ;

Zhu, Yajing .

INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (07) :1541-1551

[4] 2 EPITHELIAL TUMOR-CELL LINES (HNE-1 AND HONE-1) LATENTLY INFECTED WITH EPSTEIN-BARR VIRUS THAT WERE DERIVED FROM NASOPHARYNGEAL CARCINOMAS [J].

GLASER, R ;

ZHANG, HY ;

YAO, K ;

ZHU, HC ;

WANG, FX ;

LI, GY ;

WEN, DS ;

LI, YP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9524-9528

[5] TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/-catenin and MAPK signalling [J].

Gu, Ye ;

Wang, Qian ;

Guo, Kang ;

Qin, Weizhao ;

Liao, Wenting ;

Wang, Shuang ;

Ding, Yanqing ;

Lin, Jie .

JOURNAL OF PATHOLOGY, 2016, 239 (01) :60-71

[6] RETRACTED: IKBKE Phosphorylation and Inhibition of FOXO3a: A Mechanism of IKBKE Oncogenic Function (Retracted Article) [J].

Guo, Jian-Ping ;

Tian, Wei ;

Shu, Shaokun ;

Xin, Yu ;

Shou, Chengchao ;

Cheng, Jin Q. .

PLOS ONE, 2013, 8 (05)

[7] Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma [J].

Horikawa, Toshiyuki ;

Yang, Jing ;

Kondo, Satoru ;

Yoshizaki, Tomokazu ;

Joab, Irene ;

Furukawa, Mitsuru ;

Pagano, Joseph S. .

CANCER RESEARCH, 2007, 67 (05) :1970-1978

[8] miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway by targeting Capn4 [J].

Hu, Haili ;

Wang, Guanghui ;

Li, Congying .

ONCOTARGETS AND THERAPY, 2017, 10 :2711-2720

[9] Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization [J].

Kajihara, Takeshi ;

Jones, Marius ;

Fusi, Luca ;

Takano, Masashi ;

Feroze-Zaidi, Fakhera ;

Pirianov, Grisha ;

Mehmet, Huseyin ;

Ishihara, Osamu ;

Higham, Jenny M. ;

Lam, Eric W. -F. ;

Brosens, Jan J. .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (10) :2444-2455

[10] The significance of the Wnt pathway in the pathology of human cancers [J].

Karim, RZ ;

Tse, GMK ;

Putti, TC ;

Scolyer, RA ;

Lee, CS .

PATHOLOGY, 2004, 36 (02) :120-128

← 1 2 3 4 5 →