MicroRNAs in Cancer

被引：26
作者：
Garzon, Ramiro [1 ,2 ]
Calin, George A. [3 ]
Croce, Carlo M. [2 ,4 ]
机构：
[1] Ohio State Univ, Dept Med, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77020 USA
[4] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
来源：
ANNUAL REVIEW OF MEDICINE | 2009年 / 60卷
关键词：
tumors; oncogenes; tumor suppressors; outcome; treatment; TUMOR-SUPPRESSOR GENE; CELL-PROLIFERATION; DOWN-REGULATION; LUNG-CANCER; C-MYC; EXPRESSION; RNA; IDENTIFICATION; SIGNATURE; PROGNOSIS;
D O I：
10.1146/annurev.med.59.053006.104707
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation Of Cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs arc involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor Suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.
引用
收藏
页码：167 / 179
页数：13
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