Circulating adiponectin concentrations in patients with congestive heart failure

被引:171
作者
George, J. [1 ]
Patal, S.
Wexler, D.
Sharabi, Y.
Peleg, E.
Kamari, Y.
Grossman, E.
Sheps, D.
Keren, G.
Roth, A.
机构
[1] Tel Aviv Univ, Dept Cardiol, Sackler Sch Med, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel
[2] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel
关键词
D O I
10.1136/hrt.2005.083345
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To determine concentrations of adiponectin and its predictive value on outcome in a cohort of patients with congestive heart failure (CHF). Methods: Serum and clinical data were obtained for outpatients with clinically controlled CHF (n = 175). Serum concentrations of adiponectin, C reactive protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin (IL) -1 beta, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor a and CD-40 ligand were determined. The association of adiponectin with the clinical severity of CHF was sought as well as the predictive value of this adipokine on mortality, CHF hospitalisations or the occurrence of each of these end points. Results: Concentrations of adiponectin were significantly increased in patients with CHF. Patients with higher New York Heart Association class had significantly higher serum concentrations of adiponectin. Adiponectin serum concentrations were lower in patients with diabetes and CHF as well as in patients with ischaemic cardiomyopathy. Serum adiponectin concentration was positively associated with age and NT-proBNP but was negatively correlated with C reactive protein concentrations. Serum adiponectin above the 75th centile was found to be an independent predictor of total mortality, CHF hospitalisations or a composite of these end points over a two-year prospective follow up. Conclusion: Adiponectin is increased in CHF patients and predicts mortality and morbidity.
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收藏
页码:1420 / 1424
页数:5
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