High-sensitivity C-reactive protein: Clinical importance

被引:378
作者
Bassuk, SS [1 ]
Rifai, N [1 ]
Ridker, PM [1 ]
机构
[1] Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Boston, MA 02115 USA
关键词
D O I
10.1016/j.cpcardiol.2004.03.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
High-sensitivity C-reactive protein (hsCRP) is a marker of inflammation that predicts incident myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death among healthy individuals with no history of cardiovascular disease, and recurrent events and death in patients with acute or stable coronary syndromes. hsCRP confers additional prognostic value at all levels of cholesterol, Framingham coronary risk score, severity of the metabolic syndrome, and blood pressure, and in those with and without subclinical atherosclerosis. hsCRP levels of less than 1, 1 to 3, and greater than 3 mg/L are associated with lower, moderate, and higher cardiovascular risks, respectively. This article summarizes epidemiologic data on the relation between CRP and atherothrombotic disease and provides clinical guidelines for hsCRP screening in cardiovascular risk assessment.
引用
收藏
页码:439 / 493
页数:55
相关论文
共 230 条
[1]   Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults [J].
Abramson, JL ;
Vaccarino, V .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (11) :1286-1292
[2]   Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death [J].
Albert, CM ;
Ma, J ;
Rifai, N ;
Stampfer, MJ ;
Ridker, PM .
CIRCULATION, 2002, 105 (22) :2595-2599
[3]   Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study [J].
Albert, MA ;
Danielson, E ;
Rifai, N ;
Ridker, PM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01) :64-70
[4]   C-reactive protein levels among women of various ethnic groups living in the United States - (from the Women's Health Study) [J].
Albert, MA ;
Glynn, RJ ;
Buring, J ;
Ridker, PM .
AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (10) :1238-1242
[5]   Plasma concentration of C-reactive protein and the calculated Framingham Coronary Heart Disease Risk Score [J].
Albert, MA ;
Glynn, RJ ;
Ridker, PM .
CIRCULATION, 2003, 108 (02) :161-165
[6]   Alcohol consumption and plasma concentration of C-reactive protein [J].
Albert, MA ;
Glynn, RJ ;
Ridker, PM .
CIRCULATION, 2003, 107 (03) :443-447
[7]   Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease [J].
Anderson, JL ;
Muhlestein, JB ;
Horne, BD ;
Carlquist, JF ;
Bair, TL ;
Madsen, TE ;
Pearson, RR .
CIRCULATION, 2000, 102 (11) :1227-1232
[8]   Inflammation as a risk factor for atrial fibrillation [J].
Aviles, RJ ;
Martin, DO ;
Apperson-Hansen, C ;
Houghtaling, PL ;
Rautaharju, P ;
Kronmal, RA ;
Tracy, RP ;
Van Wagoner, DR ;
Psaty, BM ;
Lauer, MS ;
Chung, MK .
CIRCULATION, 2003, 108 (24) :3006-3010
[9]   Effects of statins on nonlipid serum markers associated with cardiovascular disease - A systematic review [J].
Balk, EM ;
Lau, J ;
Goudas, LC ;
Jordan, HS ;
Kupelnick, B ;
Kim, LU ;
Karas, RH .
ANNALS OF INTERNAL MEDICINE, 2003, 139 (08) :670-682
[10]   Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study [J].
Ballantyne, CM ;
Hoogeveen, RC ;
Bang, H ;
Coresh, J ;
Folsom, AR ;
Heiss, G ;
Sharrett, AR .
CIRCULATION, 2004, 109 (07) :837-842