α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

被引：667

作者：

Wong, Yvette C. ^{[1
]}

Krainc, Dimitri ^{[1
]}

机构：

[1] Northwestern Univ, Dept Neurol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NATURE MEDICINE | 2017年 / 23卷 / 02期

关键词：

MULTIPLE-SYSTEM ATROPHY; A-BETA COMPONENT; CHAPERONE-MEDIATED AUTOPHAGY; SPORADIC PARKINSONS-DISEASE; MIDBRAIN DOPAMINE NEURONS; SUBSTANTIA-NIGRA NEURONS; TRANSGENIC MOUSE MODEL; LEWY BODY; IN-VIVO; ALZHEIMERS-DISEASE;

D O I：

10.1038/nm.4269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in a-synuclein dosage lead to familial Parkinson's disease (PD), and its accumulation results in synucleinopathies that include PD, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Furthermore, alpha-synuclein contributes to the fibrilization of amyloid-beta and tau, two key proteins in Alzheimer's disease, which suggests a central role for alpha-synuclein toxicity in neurodegeneration. Recent studies of factors contributing to alpha-synuclein toxicity and its disruption of downstream cellular pathways, have expanded our understanding of disease pathogenesis in synucleinopathies.

引用

页码：151 / 163

页数：13

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