Construction of urease-negative mutants of Yersinia enterocolitica serotypes O:3 and O:8.: Role of urease in virulence and arthritogenicity

被引：31

作者：

Gripenberg-Lerche, C

Zhang, LJ

Ahtonen, P

Toivanen, P

Skurnik, M

机构：

[1] Turku Univ, Dept Turku, Natl Publ Hlth Inst, Turku Immunol Ctr, FIN-20520 Turku, Finland

[2] Turku Univ, Dept Med Microbiol, Natl Publ Hlth Inst, FIN-20520 Turku, Finland

[3] Turku Univ, Dept Biochem Med, Natl Publ Hlth Inst, FIN-20520 Turku, Finland

[4] Turku Univ, Dept Med, Natl Publ Hlth Inst, FIN-20520 Turku, Finland

[5] Turku Univ, Turku Ctr Biotechnol, Turku, Finland

[6] Abo Acad Univ, Turku, Finland

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 02期

关键词：

D O I：

10.1128/IAI.68.2.942-947.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Yersinia enterocolitica serotype O:3 and O:8 urease-negative mutants unable to express the 19-kDa beta subunit of urease were constructed and tested for virulence and arthritogenicity. Our results indicate that urease is needed for full virulence in oral infections and that it is not an arthritogenic factor in the rat model.

引用

页码：942 / 947

页数：6

共 30 条

[1]

Ackermann B., 1996, Arthritis and Rheumatism, V39, pS163

[2]

Ahvonen P, 1969, Acta Rheumatol Scand, V15, P232

[3]

APPLEYARD RK, 1954, GENETICS, V39, P440

[4]

AUSUBEL FM, 1987, CURRENT PROTOCOLS MO, V2