Panton-Valentine leukocidin-positive Staphylococcus aureus osteomyelitis of the tibia in a 10-year-old child

被引:5
作者
Elledge, Ross O. C. [1 ]
Dasari, Kishore K. [1 ]
Roy, Siten [1 ]
机构
[1] Sandwell Gen Hosp, Dept Trauma & Orthopaed Surg, W Bromwich, W Midlands, England
来源
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B | 2014年 / 23卷 / 04期
关键词
methicillin-resistant Staphylococcus aureus; osteomyelitis; Panton-Valentine leukocidin; METHICILLIN-RESISTANT; INFECTIONS; GUIDELINES;
D O I
10.1097/BPB.0000000000000021
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasing in prevalence among asymptomatic carriers and in cases of paediatric soft-tissue infections alike. CA-MRSA may express virulence factors such as Panton-Valentine leukocidin, which makes soft-tissue and hard-tissue infections due to such organisms challenging to treat. We report a case of osteomyelitis of the proximal tibia in a 10-year-old boy and discuss its management in what is to the authors' knowledge the first case report of Panton-Valentine leukocidin-positive CA-MRSA osteomyelitis in a child in the UK. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:358 / 363
页数:6
相关论文
共 22 条
[1]  
Alvarez-Uria G, 2012, ISRN DERMATOL, V2012
[2]   Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children [J].
Bocchini, CE ;
Hulten, KG ;
Mason, EO ;
Gonzalez, BE ;
Hammerman, WA ;
Kaplan, SL .
PEDIATRICS, 2006, 117 (02) :433-440
[3]  
Bukhari EE, 2012, SAUDI MED J, V33, P201
[4]   High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children [J].
Conceicao, T. ;
Aires-de-Sousa, M. ;
Pona, N. ;
Brito, M. J. ;
Barradas, C. ;
Coelho, R. ;
Sardinha, T. ;
Sancho, L. ;
de Sousa, G. ;
do Ceu Machado, M. ;
de Lencastre, H. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2011, 30 (02) :293-297
[5]   The Impact of Evidence-Based Clinical Practice Guidelines Applied by a Multidisciplinary Team for the Care of Children with Osteomyelitis [J].
Copley, Lawson A. B. ;
Kinsler, Major Alison ;
Gheen, Taylor ;
Shar, Adam ;
Sun, David ;
Browne, Richard .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2013, 95A (08) :686-693
[6]   Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus [J].
Dohin, Bruno ;
Gillet, Yves ;
Kohler, Remi ;
Lina, Gerard ;
Vandenesch, Francois ;
Vanhems, Philippe ;
Floret, Daniel ;
Etienne, Jerome .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2007, 26 (11) :1042-1048
[7]   A comparison of risk factors associated with community-associated methicillin-resistant and -susceptible Staphylococcus aureus infections in remote communities [J].
Golding, G. R. ;
Levett, P. N. ;
McDonald, R. R. ;
Irvine, J. ;
Nsungu, M. ;
Woods, S. ;
Horbal, A. ;
Siemens, C. G. ;
Khan, M. ;
Ofner-Agostini, M. ;
Mulvey, M. R. .
EPIDEMIOLOGY AND INFECTION, 2010, 138 (05) :730-737
[8]  
Gouveia C, 2013, CASE REP PEDIAT, V2013, P72784
[9]   Geographic Distribution of Staphylococcus aureus Causing Invasive Infections in Europe: A Molecular-Epidemiological Analysis [J].
Grundmann, Hajo ;
Aanensen, David M. ;
van den Wijngaard, Cees C. ;
Spratt, Brian G. ;
Harmsen, Dag ;
Friedrich, Alexander W. .
PLOS MEDICINE, 2010, 7 (01)
[10]  
Hall MJ, 2010, ANN R COLL SURG ENGL, V92, P17