Changes in the Blood Flow of the Femoral Artery by Botulinum Toxin A in Rats

被引：4

作者：

Hayashi, Minoru ^{[1
]}

Shimizu, Yuki ^{[1
]}

Sato, Masahide ^{[1
]}

Yokoyama, Toshiya ^{[1
]}

Yosimoto, Shinya ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Plast & Reconstruct Surg, Tokyo 1428666, Japan

来源：

ANNALS OF PLASTIC SURGERY | 2014年 / 73卷 / 01期

关键词：

botulinum toxin A; blood flow; laser Doppler flowmetry;

D O I：

10.1097/SAP.0b013e31826eabe3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We examined the changes in blood flow in the femoral artery caused by botulinum toxin A in rats. Blood flow was measured using laser Doppler flowmetry. We used male Sprague-Dawley-derived rats weighing between 350 and 400 g. The study was performed on 6 groups; each of them consisted of 30 rats (control and botulinum toxin A 0.5, 1, 2, 4, and 8 units). The laser Doppler flowmetry revealed that blood flow in the femoral artery increased by the third day in the groups injected with 1 or more units of botulinum toxin A. In the groups injected with 8 units of botulinum toxin A, we recognized an increase of blood flow from the second day. Our results suggest that botulinum toxin A is concerned in improving blood flow.

引用

页码：98 / 101

页数：4

共 11 条

[1] Aoki K. Roger, 2005, International Ophthalmology Clinics, V45, P25, DOI 10.1097/01.iio.0000167167.10402.74
[2] Carruthers A, 2008, Skin Therapy Lett, V13, P1
[3] Prevention of Anastomotic Thrombosis by Botulinum Toxin A in an Animal Model
Clemens, Mark W.
Higgins, James P.
Wilgis, E. F. Shaw
[J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2009, 123 (01) : 64 - 70
[4] KHOURI RK, 1992, CLIN PLAST SURG, V19, P773
[5] Botulinum Toxin Type A in the Treatment of Raynaud's Phenomenon
Neumeister, Michael W.
[J]. JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 2010, 35A (12): : 2085 - 2092
[6] Botox Therapy for Ischemic Digits
Neumeister, Michael W.
Chambers, Christopher B.
Herron, Margo S.
Webb, Kelli
Wietfeldt, Joel
Gillespie, Jessica N.
Bueno, Rueben A., Jr.
Cooney, Carisa M.
[J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2009, 124 (01) : 191 - 200
[7] Reconstituted botulinum type A neurotoxin: Clinical efficacy after long-term freezing before use
Parsa, Alan A.
Lye, Kevin D.
Parsa, Fereydoun Don
[J]. AESTHETIC PLASTIC SURGERY, 2007, 31 (02) : 188 - 191
[8] BOTULINUM TOXIN INJECTION INTO EXTRA-OCULAR MUSCLES AS AN ALTERNATIVE TO STRABISMUS SURGERY
SCOTT, AB
[J]. JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS, 1980, 17 (01) : 21 - 25
[9] Therapeutic use of botulinum toxins: Background and history
Setler, PE
[J]. CLINICAL JOURNAL OF PAIN, 2002, 18 (06) : S119 - S124
[10] Handling Botulinum Toxins: An Updated Literature Review
Trindade de Almeida, Ada R.
Secco, Leticia Cardoso
Carruthers, Alastair
[J]. DERMATOLOGIC SURGERY, 2011, 37 (11) : 1553 - 1565

← 1 2 →