Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern US Hospitals

被引：60

作者：

Wright, Meredith S. ^{[1
]}

Perez, Federico ^{[2
]}

Brinkac, Lauren ^{[1
]}

Jacobs, Michael R. ^{[3
,4
]}

Kaye, Keith ^{[5
]}

Cober, Eric ^{[6
]}

van Duin, David ^{[7
]}

Marshall, Steven H. ^{[2
]}

Hujer, Andrea M. ^{[2
,8
]}

Rudin, Susan D. ^{[2
,8
]}

Hujer, Kristine M. ^{[2
,8
]}

Bonomo, Robert A. ^{[2
,8
,9
,10
]}

Adams, Mark D. ^{[1
]}

机构：

[1] J Craig Venter Inst, La Jolla, CA 92037 USA

[2] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA

[3] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[4] Univ Hosp Case Med Ctr, Cleveland, OH USA

[5] Detroit Med Ctr, Detroit, MI USA

[6] Cleveland Clin, Dept Infect Dis, Cleveland, OH 44106 USA

[7] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA

[8] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[9] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA

[10] Case Western Reserve Univ, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 08期

基金：

美国国家卫生研究院;

关键词：

COMPLETE NUCLEOTIDE-SEQUENCE; MOLECULAR CHARACTERIZATION; EPIDEMIOLOGY; PLASMID; EXPANSION;

D O I：

10.1128/AAC.00125-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.

引用

页码：4961 / 4965

页数：5

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