Synthesis of 2,3,5-substituted pyrrole derivatives

被引：28

作者：

Ferreira, PMT ^{[1
]}

Maia, HLS ^{[1
]}

Monteiro, LS ^{[1
]}

机构：

[1] Univ Minho, Dept Chem, P-4700320 Braga, Portugal

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期

关键词：

dehydroalanine; dihydrofuran; pyrrole; dehydroproline;

D O I：

10.1016/S0040-4039(02)00810-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,3,5-Substituted pyrrole derivatives are prepared by treatment of 2,3-dihydrofuran derivatives with trifluoroacetic acid. These in turn are obtained by Michael addition of carbon nucleophiles of the beta-dicarbonyl type to N-(4-toluenesulfonyl)-N-(tert-butyloxycarbonyl)-dehydroalanine methyl ester. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4491 / 4493

页数：3

共 5 条

[1] Regioselective role of the hydrazide moiety in the formation of complex pyrrole-pyrazole systems [J].